Recombinant Factor VIIa in the Treatment of Bleeding
نویسندگان
چکیده
منابع مشابه
Review in translational hematology The use of recombinant factor VIIa in the treatment of bleeding disorders
Recombinant factor VIIa was initially developed for the treatment of hemorrhagic episodes in hemophilic patients with inhibitors to factors VIII and IX. After its introduction, it has also been used “off-label” to enhance hemostasis in nonhemophilic patients who experience bleeding episodes not responsive to conventional therapy. Evidence so far indicates that the use of factor VIIa in hemophil...
متن کاملBleeding after cardiac surgery - The role of recombinant factor VIIa
Cardiac surgery carries the risk of significant blood loss requiring the transfusion of blood products. In addition to such blood loss, international studies have shown that severe bleeding necessitating re-operation occurs in 3–5% of patients. Morbidity and mortality are significantly increased, so effective and safe haemostatic measures will decisively improve outcome of patients. Recombinant...
متن کامل[Bleeding after cardiac surgery: the role of recombinant factor VIIa].
Cardiac surgery carries a remarkable risk of blood loss requiring transfusion of blood products. Moreover, severe bleeding necessitating reoperation occurs in 3-5% of patients according to international studies. These patients face a significantly higher morbidity and mortality. This underscores the need for a safe and effective haemostatic therapy, which may significantly improve the outcome. ...
متن کاملThe use of recombinant factor VIIa in the treatment of bleeding disorders.
Recombinant factor VIIa was initially developed for the treatment of hemorrhagic episodes in hemophilic patients with inhibitors to factors VIII and IX. After its introduction, it has also been used "off-label" to enhance hemostasis in nonhemophilic patients who experience bleeding episodes not responsive to conventional therapy. Evidence so far indicates that the use of factor VIIa in hemophil...
متن کاملRecombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia.
BACKGROUND Recombinant factor VIIa (rFVIIa) is licensed for use in patients with haemophilia and inhibitory allo-antibodies. It is also increasingly being used for off-license indications to prevent bleeding in operations where blood loss is likely to be high, and/or to stop bleeding that is proving difficult to control by other means. OBJECTIVES To assess the effectiveness of rFVIIa when use...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2004
ISSN: 0002-9173
DOI: 10.1309/d0g0-c96v-05cj-5b4j